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BMP signalling pathway in experimental inflammatory bowel disease (CROSBI ID 585858)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa

Marić, Ivana ; Smoljan, Ivana ; Turk, Tamara ; Ćelić, Tanja ; Zoričić Cvek, Sanja ; Crnčević Orlić, Željka ; Bobinac, Dragica BMP signalling pathway in experimental inflammatory bowel disease // Bone (New York, N.Y.). 2011. str. 238-238

Podaci o odgovornosti

Marić, Ivana ; Smoljan, Ivana ; Turk, Tamara ; Ćelić, Tanja ; Zoričić Cvek, Sanja ; Crnčević Orlić, Željka ; Bobinac, Dragica

engleski

BMP signalling pathway in experimental inflammatory bowel disease

Beyond stimulating bone formation, the bone morphogenetic proteins (BMPs) are important in development, inflammation and malignancy of the gut. We have previously shown that BMP7 has a regenerative, anti-inflammatory and anti- proliferative effect on experimental inflammatory bowel disease (IBD) in rat. To further investigate the BMP signaling pathway we monitored the effect of BMP7 therapy on the BMP signaling components in rat colon during different stages of experimentally induced colitis by 2, 4, 6- trinitrobenzene sulfonic acid (TNBS). The results showed increased of BMP2 and -7 expression in the chronic phase of colitis. BMP7 treatment slightly enhanced BMP4, -6 and -7, and suppressed the BMP2 expression. CTGF and noggin expression was elevated in TNBS colitis, and slightly decreased upon BMP7 therapy. BMP receptor I expression was unchanged, while BMP receptor II was increased at day 14 and 30 of TNBS inflammation, and decreased following BMP7 therapy. BMP7 increased Smad1, Smad3 and Smad4. Inhibitory Smads were increased in colitis, but not in rats treated with BMP7. We conclude that BMP signaling is preserved in colon during TNBS-induced colonic inflammation and could be modulated with BMP7, suggesting that IBD is a reversible process with self-recovery features.

bone morphogenetic protein; inflammatory bowel disease

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Podaci o prilogu

238-238.

2011.

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objavljeno

Podaci o matičnoj publikaciji

Bone (New York, N.Y.)

Elsevier

8756-3282

Podaci o skupu

3rd joint meeting of the European Calcified Tissue Society and the International Bone and Mineral Society

poster

07.05.2011-12.05.2011

Atena, Grčka

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost