engleski

Fidelity of DNA repair and genome stability in Deinococcus radiodurans

Deinococcus radiodurans, an extremophile bacterium, resists extreme conditions of life, such as excessive desiccation and exposures to high doses of radiation or toxic chemicals. These conditions are known to severely damage the cellular genome by introducing double-strand DNA breaks – the most severe form of chromosomal damage. Genome reassembly in heavily irradiated D. radiodurans is considered to be an error-free process since no genome rearrangements were detected after post-irradiation repair. Here, we describe for the first time conditions that impair the remarkable fidelity of DNA repair in this bacterium.

Deinococcus radiodurans; DNA repair; gamma-irradiation; genome rearrangements

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