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Condensed DNA toroids in bacteriophage capsids (CROSBI ID 587313)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Šiber, Antonio Condensed DNA toroids in bacteriophage capsids // From Solid State To BioPhysics VI. 2012

Podaci o odgovornosti

Šiber, Antonio

engleski

Condensed DNA toroids in bacteriophage capsids

The shape of condensed DNA toroids is determined by the interplay of elastic energy of wound DNA and the surface energy of the DNA strands exposed on the toroid surface [1]. The hugely complicated microscopic situation with myriad of molecular interactions can be reduced to a continuum model containing only two parameters: the DNA persistence length and the »surface tension« of the DNA. Such a model predicts DNA toroid shapes which depend on a single, combined parameter mixing the elastic and surface energy contributions of the free energy. I will show how the model can be extended to study the formation of a condensed DNA toroid within a bacteriophage capsid. This involves adding a third (second) parameter to the model which signifies the effective DNA-capsid interaction. The predictions of the extended model are shown to compare favorably with experimental data [2]. The effective DNA-capsid interaction is found to depend on the condensation agent (PEG vs spermine). [1] J. Ubbink and T. Odijk, Deformation of toroidal DNA condensates under surface stress, Europhys. Lett. 33 (1996). [2] Amélie Leforestier, Antonio Šiber, Françoise Livolant and Rudolf Podgornik, Biophys. J. 100, 2209 (2011).

virus; DNA; elasticity; surface tension; condensation

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

2012.

objavljeno

Podaci o matičnoj publikaciji

From Solid State To BioPhysics VI

Podaci o skupu

From Solid State to BioPhysics VI

ostalo

09.06.2012-16.06.2012

Cavtat, Hrvatska

Povezanost rada

Fizika