Condensed DNA toroids in bacteriophage capsids (CROSBI ID 587313)
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Šiber, Antonio
engleski
Condensed DNA toroids in bacteriophage capsids
The shape of condensed DNA toroids is determined by the interplay of elastic energy of wound DNA and the surface energy of the DNA strands exposed on the toroid surface [1]. The hugely complicated microscopic situation with myriad of molecular interactions can be reduced to a continuum model containing only two parameters: the DNA persistence length and the »surface tension« of the DNA. Such a model predicts DNA toroid shapes which depend on a single, combined parameter mixing the elastic and surface energy contributions of the free energy. I will show how the model can be extended to study the formation of a condensed DNA toroid within a bacteriophage capsid. This involves adding a third (second) parameter to the model which signifies the effective DNA-capsid interaction. The predictions of the extended model are shown to compare favorably with experimental data [2]. The effective DNA-capsid interaction is found to depend on the condensation agent (PEG vs spermine). [1] J. Ubbink and T. Odijk, Deformation of toroidal DNA condensates under surface stress, Europhys. Lett. 33 (1996). [2] Amélie Leforestier, Antonio Šiber, Françoise Livolant and Rudolf Podgornik, Biophys. J. 100, 2209 (2011).
virus; DNA; elasticity; surface tension; condensation
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Podaci o prilogu
2012.
objavljeno
Podaci o matičnoj publikaciji
From Solid State To BioPhysics VI
Podaci o skupu
From Solid State to BioPhysics VI
ostalo
09.06.2012-16.06.2012
Cavtat, Hrvatska