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Pregled bibliografske jedinice broj: 584218

Časopis

Autori: Bulum, Tomislav; Duvnjak, Lea; Prkačin, Ingrid
Naslov: Estimated glucose disposal rate in assessment of renal function in patients with type 1 diabetes
Izvornik: Collegium antropologicum (0350-6134) 36 (2012), 2; 459-465
Vrsta rada: članak
Ključne riječi: diabetes mellitus type 1; estimated glucose disposal rate; urinary albumin excretion; insulin resistance
Sažetak:
Insulin resistance has been documented in type 1 diabetes and may contribute to the high risk for cardiovascular disease in this population and progression of nephropathy. We investigated associations of renal parameters, including urinary albumin excretion rate (UAE), serum creatinine and creatinine clearance, with surrogate measure of insulin sensitivity calculated using a formula derived from euglycemic-hyperinsulinemic clamp studies (estimated glucose disposal rate, eGDR). Study included 353 patients with type 1 diabetes, none showed signs of adrenal, thyroid, renal, or cardiovascular diseases. Insulin sensitivity was measured with eGDR calculated with the equation: 24.31-(12.22xWHR)-(3.29xHT)-(0.57xHbA1c). The units were mgkg-1min-1 ; WHR=waist to hip ratio ; HT=hypertension. Correlations and logistic regression analysis were performed to identify relationships between renal parameters and eGDR, individual components of insulin resistance and risk of insulin resistance. UAE and serum creatinine significantly correlated with insulin resistance measured by eGDR (r=-0.13, and -0.17, all p<0.05), and its components disorders, WHR and HbA1c. After stratifying patients in quartiles of eGDR, those in the upper quartile of the eGDR had significantly reduced levels of UAE and serum creatinine, compared to subjects in lowest quartile. In a logistic regression analysis risk for development of insulin resistance in our subjects were independently predicted only by UAE (odds ratio=1.01, p<0.01). Our results provide evidence of associations between insulin resistance and its components disorders with renal parameters, such as UAE and serum creatinine. Insulin resistance, measured with eGDR, predicts the increment in UAE in subjects with type 1 diabetes. Since progression to microalbuminuria is likely to occur in majority of diabetic patients, there is a need to further explore the role of risk factors such as insulin resistance.
Projekt / tema: 045-1080230-0516
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
SCI-EXP, SSCI i/ili A&HCI
Current Contents Connect (CCC)
Scopus
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
MEDLINE
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=126354
http://hrcak.srce.hr/file/126354
URL cjelovitog teksta:
Google Scholar: Estimated glucose disposal rate in assessment of renal function in patients with type 1 diabetes
Upisao u CROSBI: tbulum@idb.hr (tbulum@idb.hr), 18. Lip. 2012. u 18:48 sati



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