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Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty (CROSBI ID 184842)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Buljan, Melita ; Nemet, Damir ; Golubić- Čepulić, Branka ; Bićanić, Goran ; Tripković, Branko ; Delimar, Domagoj Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty // International orthopaedics, 36 (2011), 4; 703-709. doi: 10.1007/s00264-011-1367-7

Podaci o odgovornosti

Buljan, Melita ; Nemet, Damir ; Golubić- Čepulić, Branka ; Bićanić, Goran ; Tripković, Branko ; Delimar, Domagoj

engleski

Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty

Our aim was to evaluate the effectiveness of two different dosing regimens of human recombinant erythropoietin (rHu-EPO) for preoperative autologous blood collection in patients undergoing total hip arthroplasty (THA). Prospective randomised trials in which erythropoietin 15, 000 IU was administered intravenously twice a week or 30, 000 IU once a week (total 90, 000 IU) combined with ferrous II sulphate (Ferro- Gradumet 2) orally and compared with Ferro-Gradumet 2 alone. RESULTS: Although different dosing regimens of rHu-EPO administration during preoperative autologous blood donation have similar effects on the collection of two units of autologous blood, preoperative haemoglobin level and perioperative allogenic blood transfusion, a once weekly dose regimen of rHu-EPO was more convenient (although not statistically significantly) for patients. We recommend the more practical and comfortable but yet highly effective therapeutic regimen with a single weekly intravenous administration of rHu-EPO for patients scheduled for THA.

autologous blood donation ; hip arthroplasty ; human recombinant erythropoieti ; erythropoietin ; blood transfusion ; dose regimen

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Podaci o izdanju

36 (4)

2011.

703-709

objavljeno

0341-2695

10.1007/s00264-011-1367-7

Povezanost rada

Kliničke medicinske znanosti

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