Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit (CROSBI ID 185421)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Matanović-Škugor, Maja ; Štimac, Vlado ; Palej, Ivana ; Lugarić, Đurđica ; Čipčić Paljetak, Hana ; Filić, Darko ; Modrić, Marina ; Đilović, Ivica ; Gembarovski, Dubravka ; Mutak, Stjepan ; Eraković Haber, Vesna ; Holmes, David J. ; Ivezić-Schoenfeldd, Zrinka ; Alihodžić, Sulejman
engleski
Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit
The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quionolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported.
macrolide ; quinolone ; antibacterial activity ; resistance
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Podaci o izdanju
18 (17)
2010.
6547-6558
objavljeno
0968-0896
1464-3391
10.1016/j.bmc.2010.06.050