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Pregled bibliografske jedinice broj: 590091

Časopis

Autori: Jovanov-Milošević, Nataša; Petrović, Davor; Sedmak, Goran; Vukšić, Mario; Hof, Patrick; Šimić, Goran
Naslov: Human fetal tau protein isoform: possibilities for Alzheimer's disease treatment
Izvornik: International journal of biochemistry & cell biology (1357-2725) 44 (2012), 8; 1290-1294
Vrsta rada: članak
Ključne riječi: ageing; brain development; paired helical filaments-PHF; mild cognitive impairment; tau potein kinases; deafferentation; entorhinal cortex lesion
Sažetak:
While early 1990s reports showed the phosphorylation pattern of fetal tau protein to be similar to that of tau in paired helical filaments (PHF) in Alzheimer's disease (AD), neither the molecular mechanisms of the transient developmental hyperphosphorylation of tau nor reactivation of the fetal plasticity due to re- expression of fetal protein kinases in the aging and AD human brain have been sufficiently investigated. Here, we summarize the current knowledge on fetal tau, adding new data on the specific patterns of tau protein and mRNA expression in the developing human brain as well as on change in tau phosphorylation in the perforant pathway after entorhinal cortex lesion in mice. As fetal tau isoform does not form PHF even in a highly phosphorylated state, understanding its expression and post- translational modifications represents an important avenue for future research towards the development of AD treatment and prevention.
Projekt / tema: HRZZ-09/16, 108-1081870-1942
Izvorni jezik: ENG
Current Contents: DA
Citation Index: DA
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Tiskani medij: da
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S1357272512001537
http://ac.els-cdn.com/S1357272512001537/1-s2.0-S1357272512001537-main.pdf?_tid=3f990446-fb6b-11e2-85c6-00000aacb35d&acdnat=1375445062_a23d2c41a901362dc779aea5fa01f62a
Broj citata:
Altmetric:
DOI: 10.1016/j.biocel.2012.05.001
OpenURL: http://dx.doi.org/10.1016/j.biocel.2012.05.001
Google Scholar: Human fetal tau protein isoform: possibilities for Alzheimer's disease treatment
Upisao u CROSBI: gsimic@mef.hr (gsimic@mef.hr), 22. Kol. 2012. u 12:12 sati



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