Plasma nitrite concentration decreases after hyperoxia-induced oxidative stress in healthy humans (CROSBI ID 186033)
Prilog u časopisu | kratko priopćenje | međunarodna recenzija
Podaci o odgovornosti
Modun, Darko ; Krnić, Mladen ; Vuković, Jonatan ; Kokić, Višnja ; Kukoč-Modun, Lea ; Tsikas, Dimitrios ; Dujić, Željko
engleski
Plasma nitrite concentration decreases after hyperoxia-induced oxidative stress in healthy humans
The aim of this study was to measure plasma nitrite, the biochemical marker of endothelial nitric oxide (•NO) synthesis, before and after hyperoxia, in order to test the hypothesis that hyperoxia-induced vasoconstriction is a consequence of reduced bioavailability of •NO caused by elevated oxidative stress. Ten healthy men breathed 100% normobaric O 2 for 30 min between 15th and 45th min of the 1-h study protocol. Plasma nitrite and malondialdehyde (MDA), arterial stiff- ness (indicated by augmentation index, AIx) and arterial oxygen (P tc O 2 ) pressure were measured at 1st, 15th, 45th and 60th minute of the study. Breathing of nor- mobaric 100% oxygen during 30 min caused an increase in P tc O 2 (from 75 ± 2 to 412 ± 25 mm Hg), AIx (from 63 ± 4 to 51 ± 3%) and MDA (from 152 ± 13 to 218 ± 15 n M ) values and a decrease in plasma nitrite (from 918 ± 58 to 773 ± 55 n M ). During the 15-min recovery phase, plasma nitrite, AIx and MDA values remained altered. This study suggests that the underlying mechanism of hyperoxia-induced vasoconstriction may involve reduced •NO bioavailability caused by elevated and sustained oxidative stress.
arterial stiffness ; endothelium ; nitric oxide ; oxygen ; vasoconstriction
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
32 (5)
2012.
404-408
objavljeno
1475-0961
1475-097X
10.1111/j.1475-097X.2012.01133.x
Povezanost rada
Kemija, Temeljne medicinske znanosti, Kliničke medicinske znanosti