Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Improved sensitization of CD8+ T cell response after infection with MCMV expressing NKG2D ligand (CROSBI ID 589869)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Tršan, Tihana ; Slavuljica, Irena ; Busche, Andreas ; Babić Čač, Marina, ; Golemac, Mijo ; Mihelčić, Mirna ; Abram, Maja ; Krmpotić, Astrid ; Messerle, Martin ; Jonjić, Stipan Improved sensitization of CD8+ T cell response after infection with MCMV expressing NKG2D ligand // 2011 Annual Meeting of the Croatian Immunological Society. 2011

Podaci o odgovornosti

Tršan, Tihana ; Slavuljica, Irena ; Busche, Andreas ; Babić Čač, Marina, ; Golemac, Mijo ; Mihelčić, Mirna ; Abram, Maja ; Krmpotić, Astrid ; Messerle, Martin ; Jonjić, Stipan

engleski

Improved sensitization of CD8+ T cell response after infection with MCMV expressing NKG2D ligand

We have developed a recombinant mouse cytomegalovirus expressing high affinity NKG2D ligand Rae-1γ (RAE-1γ MCMV). NKG2D is a potent activating receptor expressed by cells of both innate and adaptive immunity. Its importance in CMV immunosurveillance is indicated by the elaborative viral evasion mechanisms evolved to avoid NKG2D. Expression of Rae-1γ by MCMV resulted in profound virus attenuation in vivo. Infection was efficiently controlled by adult and immunologically immature neonatal host as well as immunodeficient hosts. RAE-1γ MCMV was also highly attenuated in naturally more resistant C57BL/6 mice and induced even stronger virus specific CD8+ T cell response upon higher viral load. At early days post infection RAE-1γ MCMV decreased systemic IFNα level, preserved conventional dendritic cells and promoted effector CD8+ T cell response. Despite tight immune control, RAE-1γMCMV infection elicited strong, long-lasting protective immunity. These results prompted us to test vector capacity of Rae-1γ MCMV. Our results indicate that a recombinant virus encoding ligand for the NKG2D receptor might provide a new, powerful approach for development of a safe immunogenic CMV vaccine as well as CMV-based vaccine vector.

Cytomegalovirus; NKG2D; NKG2D ligands; CMV vaccine vector; CD8 T cell vaccine

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

2011.

objavljeno

Podaci o matičnoj publikaciji

2011 Annual Meeting of the Croatian Immunological Society

Podaci o skupu

Godišnji skup Hrvatskog imunološkog društva, Rabac 2011.

poster

07.10.2011-09.10.2011

Rabac, Hrvatska

Povezanost rada

Temeljne medicinske znanosti