engleski

The novel 6-(N-pyrrolyl)purine acyclic nucleosides: H-1 and C-13 NMR and X-ray structural study

Synthesis of the novel nucleoside analogues containing exocyclic pyrrolo moiety and acyclic side chains attached to the purine ring at N-9 and N-7 is described. The site of alkylation was determined by 1H and 13C NMR on the basis of chemical shifts, C-H coupling constants and connectivity in NOESY and HETCOR spectra. The N-9 substitution of 7 was proved by its X-ray crystallographic analysis.

acyclic purine nucleosides ; N-9 and N-7 regioisomers ; 1H NMR ; 13C NMR ; NOESY ; HETCOR ; X-ray crystallography

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