Antigenic Differences between Vaccine and Circulating Wild Type Mumps Viruses Decreases Neutralization Capacity of Vaccine Induced Antibodies (CROSBI ID 186691)
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Podaci o odgovornosti
Šantak, Maja ; Lang Balija, Maja ; Ivančić-Jelečki, Jelena ; Košutić Gulija, Tanja ; Ljubin Sternak, Sunčanica ; Forčić, Dubravko
engleski
Antigenic Differences between Vaccine and Circulating Wild Type Mumps Viruses Decreases Neutralization Capacity of Vaccine Induced Antibodies
Recent resurgence of mumps in doubly vaccinated cohorts has been notified, identifying genotype G as a predominant genotype nowadays. In this study, the neutralization efficacy of guinea pig’s sera immunized with three vaccine viruses: L-Zagreb, Urabe AM9 and JL5, was tested against seven mumps viruses: the three vaccine strains and four wild type strains (two of genotype G, one of genotype C and one of genotype D) isolated from 1998 until 2011. All sera neutralized all viruses although at different level. The neutralization efficiency of sera decreases several fold by temporal order of virus isolation. Therefore, we conclude that gradual evolution of mumps viruses, rather than belonging to a certain genotype, results in an antigenic divergence from the vaccine strains what decreases the neutralization capacity of vaccine induced antibodies. Also, the amino acid sequence alignment revealed three new potentially relevant regions for the escape from neutralization 113-130, 375-403 and 440-443.
mumps virus; mumps vaccine; neutralization antibodies
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Podaci o izdanju
Povezanost rada
Javno zdravstvo i zdravstvena zaštita, Biotehnologija, Biologija