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Effect of Indomethacin on Free Fatty Acid Level after Experimental Spinal Cord Injury in Rabbits (CROSBI ID 478461)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Pantović, Radojka ; Draganić, Pero ; Blagović, Branka ; Rupčić, Jasminka ; Eraković, Vesna ; Simonić, Ante ; Milin, Čedomila Effect of Indomethacin on Free Fatty Acid Level after Experimental Spinal Cord Injury in Rabbits // Kongres hrvatskih biokemičara i molekularnih biologa : sažeci. 2000. str. 84-84

Podaci o odgovornosti

Pantović, Radojka ; Draganić, Pero ; Blagović, Branka ; Rupčić, Jasminka ; Eraković, Vesna ; Simonić, Ante ; Milin, Čedomila

engleski

Effect of Indomethacin on Free Fatty Acid Level after Experimental Spinal Cord Injury in Rabbits

The effect of indomethacin on free fatty acids (FFA) level was evaluated in an experimental model of spinal cord impact injury in rabbits. Indomethacin, a potent inhibitor of endogenous prostaglandin synthesis was tested in the doses of 0, 1 ; 0, 3 ; 1, 0 and 3, 0 mg/kg of body weight. The spinal cord of all decapitated animals was taken out and frozen in liquid nitrogen. For the isolation and purification of total lipids a modified method by Folch was used. The free fatty acids were separated from total lipid extract by preparative thin-layer chromatography (TLC) and after methylation identified and quantified by gas chromatography. The results of our experiments showed that indomethacin induces significant changes in the level of evaluated biochemical parameters.

indomethacin; free fatty acids; spinal cord; rabbits

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Podaci o prilogu

84-84.

2000.

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objavljeno

Podaci o matičnoj publikaciji

Kongres hrvatskih biokemičara i molekularnih biologa : sažeci

Podaci o skupu

KONGRES HRVATSKIH BIOKEMIČARA I MOLEKULARNIH BIOLOGA

poster

13.10.2000-15.10.2000

Zagreb, Hrvatska

Povezanost rada

Kliničke medicinske znanosti