The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence. (CROSBI ID 187140)
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Podaci o odgovornosti
Nikolac, Matea ; Šagud, Marina ; Nedić, Gordana ; Nenadić Šviglin, Korona ; Mihaljević Peleš, Alma ; Uzun, Suzana ; Vuskan Čusa, Bjanka ; Kozumplik, Oliver ; Živković, Maja ; Mustapić, Maja ; Jakovljević, Miro ; Pavlović, Mladen ; Muck-Šeler, Dorotea ; Borovečki, Fran ; Pivac, Nela
engleski
The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence.
The study elucidated the association between the COMT Val108/158Met polymorphism and smoking in patients with schizophrenia, patients with alcohol dependence and healthy control subjects. The stepwise logistic regression (odds ratio (OR)=1.56, 95% confidence interval (CI)=1.10–2.23, P=0.014) and the χ2 test (P=0.008) revealed that the COMT Val/Val genotype was significantly associated with smoking in healthy male subjects. Although the hypothesis of the study was that COMT Val108/158Met genotypes will be significantly associated with smoking in schizophrenia and alcohol dependence, our study showed for the first time the lack of significant association between smoking and COMT Val108/158Met polymorphism in schizophrenia, and confirmed no association between smoking and COMT Val108/158Met in alcoholism.
catechol-O-methyltransferase (COMT); shizophrenia; alcohol dependence; smoking; association study
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti