Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Decidual macrophages are the population of decidual adherent cells which regulates perforin expression in cytolytic cells (CROSBI ID 90863)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Sotošek, Vlatka ; Laškarin, Gordana ; Štrbo, Nataša ; Dohr, Gottfried ; Blaschitz, Astrid ; Podack, Eckhard R. ; Rukavina, Daniel Decidual macrophages are the population of decidual adherent cells which regulates perforin expression in cytolytic cells // American journal of reproductive immunology, 42 (1999), 2; 76-82. doi: 10.1111/j.1600-0897.1999.tb00469.x

Podaci o odgovornosti

Sotošek, Vlatka ; Laškarin, Gordana ; Štrbo, Nataša ; Dohr, Gottfried ; Blaschitz, Astrid ; Podack, Eckhard R. ; Rukavina, Daniel

engleski

Decidual macrophages are the population of decidual adherent cells which regulates perforin expression in cytolytic cells

PROBLEM: We have shown that addition of decidual adherent cells (DAC) to the culture of decidual lymphocytes (DL) prevents the downregulation of perforin expression in these cells. Because DAC are a mixture of various cell populations, the aim is to analyze immunophenotypic characteristics of DAC and to determine which cell population is involved in the regulation of perforin expression. METHOD OF STUDY: First trimester pregnancy decidual cells were obtained by enzymatic tissue digestion. Decidual cells and peripheral blood lymphocytes (PBL) were centrifuged on Ficoll-Hypaque density gradient and cultured overnight to obtain adherent cells, which were analyzed by flow cytometry and immunocytochemically. RESULTS: Almost all peripheral blood adherent cells (PBAC) (ca 90%) expressed monocyte/macrophage markers but only 10–20% of DAC. The rest of DAC expressed markers of stromal cells. HLA-DR depleted population of DAC (stromal cells only) could not prevent downregulation of perforin expression in cultured DL and PBL. CONCLUSION: Decidual macrophages are involved in the regulation of perforin expression in DL.

Perforin ; Peripheral blood lymphocytes ; Natural killer cells ; Macrophages ; Decidua ; Pregnancy

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

42 (2)

1999.

76-82

objavljeno

1600-0897

10.1111/j.1600-0897.1999.tb00469.x

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost