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Progesterone directly and indirectly affects perforin expression in cytolytic cells (CROSBI ID 90866)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Laškarin, Gordana ; Faust, Zsuzsa ; Štrbo, Nataša ; Sotošek, Vlatka ; Podack, Eckhard R. ; Szekeres-Bartho, Julia ; Rukavina, Daniel Progesterone directly and indirectly affects perforin expression in cytolytic cells // American journal of reproductive immunology, 42 (1999), 5; 312-320. doi: 10.1111/j.1600-0897.1999.tb00107.x

Podaci o odgovornosti

Laškarin, Gordana ; Faust, Zsuzsa ; Štrbo, Nataša ; Sotošek, Vlatka ; Podack, Eckhard R. ; Szekeres-Bartho, Julia ; Rukavina, Daniel

engleski

Progesterone directly and indirectly affects perforin expression in cytolytic cells

Decidual lymphocytes (DL) expressing the cytolytic molecule perforin represent approximately 55% of DL in the first trimester of human pregnancy. Progesterone dominates this phase of pregnancy and controls the production of uterine cytokines and growth factors. The aim of this study was to investigate the role of progesterone and progesterone-induced blocking factor (PIBF) on perforin expression in DL and peripheral blood lymphocytes (PBL). Perforin expression was analyzed in PBL and DL incubated either in culture medium or with decidual adherent cells (DAC) and peripheral blood adherent cells (PBAC) and their supernatants with or without progesterone or PIBF. Perforin was detected by flow cytometry in PB and in decidual first trimester pregnancy lymphocytes. Progesterone in high concentrations directly affects perforin expression in DL but not in PBL. Progesterone in a concentration dependent manner indirectly blocks perforin expression in DL and PBL cultured with adherent cells or their supernatants. PIBF blocked upregulation of perforin expression of DL cultured with DAC, but none of those cultured with PBAC. Similarly, PIBF was inefficient when PBL or DL were cultured with PBAC. Progesterone present in a high concentration locally at the maternal-fetal interface modulates perforin expression in the first trimester pregnancy DL.

progesterone ; progesterone induced blocking factor (PIBF) ; Perforin ; NK cells ; cytolytic iymphocytes ; decidua ; peripheral blood

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

42 (5)

1999.

312-320

objavljeno

1600-0897

10.1111/j.1600-0897.1999.tb00107.x

Povezanost rada

Temeljne medicinske znanosti

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