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A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways (CROSBI ID 188210)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Hewitt, V.L. ; Heinz, E. ; Shingu-Vazquez, M. ; Qu, Y. ; Jeličić, Branka ; Lo, T.L. ; Beilharz, T.H. ; Dumsday, G. ; Gabriel, K. ; Traven, Ana et al. A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways // Proceedings of the National Academy of Sciences of the United States of America, 109 (2012), 49; E3358-E3366. doi: 10.1073/pnas.1206345109

Podaci o odgovornosti

Hewitt, V.L. ; Heinz, E. ; Shingu-Vazquez, M. ; Qu, Y. ; Jeličić, Branka ; Lo, T.L. ; Beilharz, T.H. ; Dumsday, G. ; Gabriel, K. ; Traven, Ana ; Lithgow, T.

engleski

A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways

The controlled biogenesis of mitochondria is a key cellular system coordinated with the cell division cycle, and major efforts in systems biology currently are directed toward understanding of the control points at which this coordination is achieved. Here we present insights into the function, evolution, and regulation of mitochondrial biogenesis through the study of the protein import machinery in the human fungal pathogen, Candida albicans. Features that distinguish C. albicans from baker's yeast (Saccharomyces cerevisiae) include the stringency of metabolic control at the level of oxygen consumption, the potential for ATP exchange through the porin in the outer membrane, and components and domains in the sorting and assembling machinery complex, a molecular machine that drives the assembly of proteins in the outer mitochondrial membrane. Analysis of targeting sequences and assays of mitochondrial protein import show that components of the electron transport chain are imported by distinct pathways in C. albicans and S. cerevisiae, representing an evolutionary rewiring of mitochondrial import pathways. We suggest that studies using this pathogen as a model system for mitochondrial biogenesis will greatly enhance our knowledge of how mitochondria are made and controlled through the course of the cell-division cycle.

mitochondrial biogenesis

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Podaci o izdanju

109 (49)

2012.

E3358-E3366

objavljeno

0027-8424

10.1073/pnas.1206345109

Povezanost rada

Biologija

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