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Pregled bibliografske jedinice broj: 609479

Časopis

Autori: Duvnjak, Lea; Kokić, Višnja; Bulum, Tomislav; Kokić, Slaven; Krnić, Mladen; Hozo, Izet
Naslov: The metabolic syndrome is associated with high-normal urinary albumin excretion and retinopathy in normoalbuminuric type 1 diabetic patients
Izvornik: Collegium antropologicum (0350-6134) 36 (2012), 4; 1373-1378
Vrsta rada: članak
Ključne riječi: metabolic syndrome; diabetes type 1; microvascular complications; urinary albumin excretion; retinopathy
Sažetak:
Although metabolic syndrome was not extensively studied in type 1 diabetes, higher insulin resistance, the core feature of the syndrome was found to be associated with increased risk of developing microvascular complications. As diabetic nephropathy may progress to advanced lesion before microalbuminuria appears, we investigated the association of the metabolic syndrome and estimated glucose disposal rate (eGDR) with urinary albumin excretion (UAE), retinopathy and neuropathy in normoalbuminuric type 1 diabetic patients. Two hundred and 98 patients (UAE <30 mg / 24 h at three occasions) were divided according to the IDF metabolic syndrome ; eGDR (mg kg–1 min–1) was calculated: 24.31–(12.22 ´ WHR) – (3.29 ´ HT) – (0.57 ´ HbA1c), (WHR=waist-to-hip ratio, HT=hypertension). Patients with (n=99) compared to those without metabolic syndrome (N=199) showed higher UAE (15.96±9.10 ; 13.48±8.36 mg / 24 h), C-reactive protein (2.39±4.09 ; 1.12±2.03 mg/L), prevalence of retinopathy (70.7 ; 55.27%) and polyneuropathy (80.8 ; 68.3%), and lower eGDR (5.75±1.74 ; 8.96±1.9), (p>0.05). In patients with high-normal UAE, retinopathy and polyneuropathy eGDR was significantly lower compared with patients with low-normal UAE, and without retinopathy and polyneuropathy. In multiple regression analysis UAE and retinopathy were associated with diabetes duration (b= –0.20, b= –0.62), eGDR (b= – 0.106 ; b= –0.041), metabolic syndrome (b=0.49, b=0.28), (p>0.05). In type 1 diabetic patients insulin resistance and IDF defined metabolic syndrome are associated with high-normal UAE, retinopathy and polyneuropathy. The predictive value of the metabo
Projekt / tema: 045-1080230-0516
Izvorni jezik: ENG
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bazama podataka:
SCI-EXP, SSCI i/ili A&HCI
Current Contents Connect (CCC)
Scopus
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
MEDLINE
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=139824
http://hrcak.srce.hr/file/139824
URL cjelovitog teksta:
Google Scholar: The metabolic syndrome is associated with high-normal urinary albumin excretion and retinopathy in normoalbuminuric type 1 diabetic patients
Upisao u CROSBI: tbulum@idb.hr (tbulum@idb.hr), 29. Pro. 2012. u 20:56 sati



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