BMP-6 restores bone in osteoporotic aged rats and, unlike estradiol and PTH, restores trabecular bone in ovariectomized BMP-6 knockout mice. (CROSBI ID 594173)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Šimić, Petra ; Buljan Culej, Jasminka ; Orlić, Iva ; Borovečki, Fran ; Vukičević, Slobodan
engleski
BMP-6 restores bone in osteoporotic aged rats and, unlike estradiol and PTH, restores trabecular bone in ovariectomized BMP-6 knockout mice.
BMP-6 applied systemically to aged OVX rats significantly increased bone volume and mechanical characteristics of both the trabecular and cortical bone, the osteoblast surface, serum osteocalcin and osteoprotegerin levels, and decreased the osteoclast surface, serum C-telopeptide, and interleukin-6. E2 was significantly less effective, and was not synergistic with BMP-6. Animals that discontinued BMP-6 therapy maintained bone mineral density gains for another 12 weeks. BMP-6 increased in vivo the bone expression of Acvr-1, Bmpr1b, Smad5, alkaline phosphatase, and collagen type I and decreased expression of Bmp3 and BMP antagonists, chordin and cerberus. These results show, for the first time, that systemically administered BMP-6 restores the bone inductive capacity, microarchitecture, and quality of the skeleton in osteoporotic rats.
BMP-6; aged OVX rats;; alkaline phosphatase; collagen type I
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Podaci o prilogu
2005.
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objavljeno
Podaci o matičnoj publikaciji
0884-0431
Podaci o skupu
ASBMR 27th Annual Meeting
predavanje
23.09.2005-27.09.2005
Nashville (TN), Sjedinjene Američke Države