engleski

Mould growth and aflatoxin accumulation in the presence of newly synthesized analogues of dehydroacetic acid

Dehydroacetic acid (DHA) and its newly synthesized analogues, 4-hydroxy-3(p-toluoyl)-6-(p-tolil)-2H-pyrane-2-one (DHT) and 5-bromo-4-hydroxy-3-(p-toluoyl)-6-(p-tolil)-2H-pyrane-2-one (BrDHT), were tested for antifungal and antiaflatoxigenic activity against Aspergillus parasiticus NRRL 2999. DHT and DHA concn of 3, 0 µM and 6, 0 µM, respectively, stimulated mould growth and aflatoxin B1 and G1 synthesis, but concn >30, 0µM produced an inhibitory effect. In the presence of low BrDHT concn mould growth decreased by 70% and toxin concn by 85 and 90%, respectively.

DHA; BrDHT; antifungal; and antiaflatoxigenic activity; Aspergillus parasiticus; aflatoxin B1 and G1

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