PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele (CROSBI ID 190464)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Musani, Vesna ; Sabol, Maja ; Car, Diana ; Ozretić, Petar ; Kalafatić, Držislav ; Maurac, Ivana ; Orešković, Slavko ; Levanat, Sonja
engleski
PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele
In this study we investigated the types and role of different genetic changes of PTCH1 gene in three different types of ovarian tumors: carcinomas, fibromas and dermoids. LOH of the PTCH1 region was detected in 27.3% ovarian carcinoma samples, 18.18% ovarian fibroma samples and 55.56% ovarian dermoid samples. No point mutations were detected in any of the three types of ovarian tumors. SNP c.3944C>T showed significant differences between ovarian carcinoma and control samples with the minor T allele being significantly higher in controls compared to ovarian carcinomas. Interestingly, a new polymorphism c.−1184G>A was found only in tumor samples and further analyses should be performed in order to elucidate its potential role in ovarian tumors.
PTCH1; polymorphism; LOH; ovarian tumors
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti