Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele (CROSBI ID 190464)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Musani, Vesna ; Sabol, Maja ; Car, Diana ; Ozretić, Petar ; Kalafatić, Držislav ; Maurac, Ivana ; Orešković, Slavko ; Levanat, Sonja PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele // Gene, 517 (2013), 1; 55-59. doi: 10.1016/j.gene.2012.12.089

Podaci o odgovornosti

Musani, Vesna ; Sabol, Maja ; Car, Diana ; Ozretić, Petar ; Kalafatić, Držislav ; Maurac, Ivana ; Orešković, Slavko ; Levanat, Sonja

engleski

PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele

In this study we investigated the types and role of different genetic changes of PTCH1 gene in three different types of ovarian tumors: carcinomas, fibromas and dermoids. LOH of the PTCH1 region was detected in 27.3% ovarian carcinoma samples, 18.18% ovarian fibroma samples and 55.56% ovarian dermoid samples. No point mutations were detected in any of the three types of ovarian tumors. SNP c.3944C>T showed significant differences between ovarian carcinoma and control samples with the minor T allele being significantly higher in controls compared to ovarian carcinomas. Interestingly, a new polymorphism c.−1184G>A was found only in tumor samples and further analyses should be performed in order to elucidate its potential role in ovarian tumors.

PTCH1; polymorphism; LOH; ovarian tumors

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

517 (1)

2013.

55-59

objavljeno

0378-1119

10.1016/j.gene.2012.12.089

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost