Endemic nephropathy is aristolochic acid nephropathy: a urological controversy resolved. (CROSBI ID 594852)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Dittrich, Damir ; Medverec, Zvonimir ; Jakovina, Krunoslav ; Jakovina, Tratinčica ; Tomić, Karla ; Stipanić, Žellimir ; Vuković Lela, Ivana ; Karanović, Sandra ; Grollman, Arthur P ; Jelaković, Bojan.
engleski
Endemic nephropathy is aristolochic acid nephropathy: a urological controversy resolved.
Endemic (Balkan) nephropathy (EN) is characterized by an insidious onset, slow progression to end stage renal disease and a strong association with upper urinary tract cancers (UUC). EN occurs only in rural villages, situated near tributaries of the Danube River ; epidemiologic studies reveal a familial aggregation, but not an inherited disease. Various environmental agents, including ocratoxin A have been proposed as putative causative factors of EN but strong evidence in support of these hypotheses in lacking. We have proposed that chronic dietary exposure to aristolochic acid (AA) is genetically susceptible individuals is uniquely responsible for EN and UUC. This hypothesis is supported by the unquivocal detection of 7-(deoxyadenosin_N6-yl) aristolactam DNA adducts in renal cortical and UUC tissues of patients with EN and/or UUC.
Endemic nephropathy; aristolochic acid
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Podaci o prilogu
A7-A8.
2010.
objavljeno
Podaci o matičnoj publikaciji
Abstract Book
Podaci o skupu
The 3rd World Congress on Controversies in Urology
poster
25.02.2010-28.02.2010
Atena, Grčka