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Plasma viscosity and its relationship to serum sialic acid in type 1 diabetes mellitus

Increased plasma viscosity (PV) may be an aggravating factor promoting microvascular and macrovascular damage in patients with type 1 diabetes mellitus. The possible association of PV to serum total sialic acid (TSA), another cardiovascular risk and a marker of acute phase reaction are not well established. We have studied 59 patients with type 1 diabetes whitout compications (Group 1), 40 patients with one (Group 2) and 65 patients with two verified complications- retinopathy and/or nephrpathy (Group 3). The mean values + SD of age (yr.; diabetes duration (yr.) and HbA1C were: 32.1+ 12.4; 4.6+4.2 and 8.2+2 in Group 1: 40.5+13.6; 10.9+6.7 and 8.8+1.9 in Group 2, and 46.2+13.9; 17.4+8.9 and 8.5+1.7 in Group 3. A significantly higher levels of PV was observed in Group 2 (p 0.05) and Group # (p 0.005) compared to that in Group 1. TSA was significantly higher (p 0.05) only in Group3 compared to Group 1. In type 1 diabetic patients without complications PV did not correlate to TSA concentration. On the contrary, this correlation was significant in patients with one complication (R=0.44, p 0.05) and in patients with two complications (r=0.46, p 0.05). These results suggest that both plasma viscosity and total serum sialic acid in type 1 diabetic patients increase most probably as results of acute phase reaction in relation to the presence of diabetic complications.

plasma viscosity; sialic acid; type 1 diabetes

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