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The transforming properties of human papillomavirus oncoproteins (CROSBI ID 191775)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Grce, Magdalena ; Sabol, Ivan ; Milutin Gašperov, Nina The transforming properties of human papillomavirus oncoproteins // Periodicum biologorum, 114 (2012), 4; 479-487

Podaci o odgovornosti

Grce, Magdalena ; Sabol, Ivan ; Milutin Gašperov, Nina

engleski

The transforming properties of human papillomavirus oncoproteins

Human papillomaviruses (HPV) are very common viruses, often causing benign epithelial lesions but, rarely, also cancer. Only long persistent infection with some carcinogenic or high risk HPV types will progress to high-grade lesions and finally cancer. The oncogenic potential of these HR HPV types relies on the role of their major oncoproteins E6 and E7, which bind, inactivate and degrade the two major cellular tumor-suppressor gene products, p53 and the retinoblastoma tumor-suppressor protein (pRb), respectively. The continuous expression of these early oncoproteins can lead to the transformation and immortalization of infected cells. Both, E6 and E7 co-operate to induce transformation of epithelial cells by interacting with numerous host cell proteins affectingmany essential cellular pathways. Herein, the current knowledge on HPV E6 and E7, as well as on the auxiliary E5 oncoprotein is summarized.

human papillomavirus ; HPV ; oncogene ; oncoprotein

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Podaci o izdanju

114 (4)

2012.

479-487

objavljeno

0031-5362

Povezanost rada

Temeljne medicinske znanosti

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