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Association between CYP2D6 polymorphism and the susceptibility to alcohol liver disease (ALD (CROSBI ID 479261)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Štefanović, Mario ; Ivanišević, Ana-Maria ; Topić, Elizabeta Association between CYP2D6 polymorphism and the susceptibility to alcohol liver disease (ALD // Clin Chem Lab Med 1999;vol 37:Abstracts volume, Special supplement / Schaffner, W. (ur.). Milano: Walter de Gruyter, 1999. str. S152-x

Podaci o odgovornosti

Štefanović, Mario ; Ivanišević, Ana-Maria ; Topić, Elizabeta

engleski

Association between CYP2D6 polymorphism and the susceptibility to alcohol liver disease (ALD

Genetic polymorphism of cytochromes P450 could be implicated in the individual susceptibility of alcoholics to ethanol induced diseases. Our aim was to examine the possible association of the CYP2D6*3 and *4 null alleles with ALD. Genotyping was carried out on 53 controls and 37 ALD patients by PCR-SSCP on whole blood DNA: PCR products were denaturated, chilled on ice, run on electrophoresis and visualized with SYBR Green II. Study results showed that for control group allelic frequencies for *3 and *4 alleles were 0.9% and 17% respectively. Among controls we found 1/53 (1.9%) *3 and 16/53 (29.5%) *4 heterozygotes; 1/53 (2.3%) *4 homozygote, whereas *3 homozygote was not identified. Among ALD patients, allelic frequencies for *3 and *4 alleles were 4.1% and 14.7%, respectively. For *3 and *4 alleles 3/37 (8.1%) and 11/37 (29.4%) patients were heterozygous, respectively. We observed neither *3 nor *4 homozygotes in the patient group. Frequencies for *3 and *4 alleles did not differ significantly, whereas genotype frequencies differed between groups, however not significantly. To verify the possible contribution of *3 and *4 null allelic genotypes in development of ALD, further study with expanded groups is needed.

CYP2D6; alcohol liver disease

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Podaci o prilogu

S152-x.

1999.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Clin Chem Lab Med 1999;vol 37:Abstracts volume, Special supplement

Schaffner, W.

Milano: Walter de Gruyter

Podaci o skupu

IFCC-World lab, 17th International and 13th European Congress of Clinical Chemistry and Laboratory Medicine

poster

06.06.1999-11.06.1999

Firenca, Italija

Povezanost rada

Temeljne medicinske znanosti