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Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients

Studies have suggested a positive association between dyslipidemia and advanced chronic kidney disease, but the relation between these markers and normal or mild renal dysfunction has not been well investigated. The aim of this study was to investigate the associations of serum lipids, including total, LDL, HDL, HDL2, HDL3, VLDL cholesterol, and triglyceride levels with estimated glomerular filtration rate (eGFR) in normoalbuminuric type 1 diabetic patients. Study included 313 normoalbuminuric (UAE <30.0 mg/24h based on median UAE of at least two 24-h urine collections) type 1 diabetic patients with normal or mild decrease (eGFR > 60 mlmin-1 1.73 m2) renal function and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. eGFR was significantly associated with total, LDL, HDL, HDL2, and HDL3 cholesterol (r=-0.21, -0.18, -0.17, -0.21, and -0.14, respectively, for all p<0.05). Stratifying serum lipids for degree of eGFR (60-90, >90 mlmin-1 1.73 m2) levels of total, LDL, HDL and HDL2 cholesterol were inversely related to eGFR, but trends were significant only for total (5.1 vs 4.6 mmol/L, p=0.02) and LDL cholesterol (2.9 vs 2.4 mmol/L, p=0.006). In this study we have shown that higher total and LDL cholesterol are associated with worsening of renal function normoalbuminuric type 1 diabetic patients. Prospective studies are needed to evaluate whether the observed lipid abnormalities play a role in the progression of renal function in type 1 diabetic patients.

type 1 diabetes; serum lipids; renal function; glomerular filtration rate

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