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SINTEZA I BIOLOŠKA AKTIVNOST DERIVATA BENZIMIDAZOLA I BENZIMIDAZO[1, 2-a]KINOLINA

Benzimidazoles represent the major backbone of numerous of synthetic medicinal and biochemical agents possessing different chemical and pharmacological features which impart them diverse biological properties. Recently, as a part of our continues scientific research in the field of potential, biologically active benzimidazoles, we have reported on the synthesis and biological activity of several groups of 2-styryl substituted benzimidazoles and benzimidazo[1, 2-a]quinolines and their heteroaromatic analogues, including positively charged amidino and amino substituted derivatives [1-2]. Biological studies confirmed the strong anticancer potential of this class of compounds while DNA/RNA binding studies revealed intercalation into ds DNA or RNA, especially of positively charged amidino substituted benzimidazo[1, 2-a]quinolines. Due to high fluorescence intensity and excellent spectroscopic characteristics, fused benzimidazoles offer also a potential application as fluorescent probes for detection of biological important molecules in biomedical diagnostics or as chemosensors that are capable of assaying cations in solution.

benzimidazo[1; 2-a]quinolines; antiproliferative activity; interaction with ct-DNA; fluorescent probes; chemosensors

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