engleski

Primary renal angiosarcoma

Angiosarcomas are localized or multicentric tumors with various grades of differentiation that originate in the endothelium of the blood and lymphatic vessels. Angiosarcoma is an extremely aggressive malignant neoplasm with a 6-month median survival. Primary occurrence in the kidney is rare, with 24 cases described to date. We present a case of primary renal angiosarcoma in a 65-year-old male patient. It was an incidental CT scan finding that showed 3 tumors in the left kidney. Nephrectomy with ureterectomy was performed. Macroscopic examination revealed 3 nodular hemorrhagic yellowish tumors located subcapsularly in the central area of the left kidney, measuring 0.5 to 4.5 cm in diameter. Microscopically, it was a malignant neoplasm composed of large sheets, cords and small anastomosing vascular spaces, covered by pleomorphic epithelioid and spindle-shaped cells with voluminous and hyperchromatic irregular nuclei. Mitotic figures were frequent. Immunohistochemically, neoplastic cells showed strong positivity for C31, C34 and factor VIII. In conclusion, primary renal angiosarcomas are extremely rare aggressive tumors of endothelial cells. About 24 cases of this tumor have been documented. The mean patient age is 58 years. The etiology is unknown. They usually occur near renal capsule. Clinical symptoms are flank pain and hematuria. Differential diagnosis includes retroperitoneal hematoma and hemorrhagic renal tumors. The prognosis of renal angiosarcoma is poor, with rapid development of hematogenous metastasis.

renal angiosarcoma

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