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Morphology, mechanical properties and bioactivity of PCL coated hydroxyapatite scaffold derived from cuttlefish bone

Mechanical properties of highly porous hydroxyapatite (HA) scaffold derived from aragonitic cuttlefish bone were improved by coating with 20wt. % solution of polycaprolactone (PCL).The phase composition and microstructure of the scaffold were examined by XRD, TGA, FTIR and SEM. Bioactivity was tested by immersion in HBSS and mechanical tests were performed at compression. SEM observation of the HA/PCL scaffold revealed a thin film of PCL covering the original architecture of cuttlefish bone. Bioactivity test showed the precipitation of calcium deficient HA particles with molar ratio (Ca/P = 1.58) in both HA and HA/PCL scaffolds. A novel HA/PCL bioactive scaffold with enhanced mechanical properties has been prepared preserving the natural well interconnected porous structure of cuttlefish bone. The scaffold could be suitable for cell attachment, proliferation and differentiation and could be used in bone tissue engineering applications [1]. References: [1] B.S. Kim, J.S. Kim, H.M. Sung, H.K. You, J. Lee, J Biomed Mater Res A.(2012) 100(7):1673-9

hydroxyapatite/polycaprolactone scaffold; morphology; mechanical properties; bioactivity

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