engleski

Mitochondrial DNA variability in Macedonians and Macedonian Romani: implication to the role in human forensic identification

In this study we have analyzed a mitochondrial DNA diversity in a sample of 140 unrelated autochthonous Macedonians and 159 Macedonian Romany, representing different ethnical groups residing within the same country of Republic of Macedonia. Based on high resolution analysis of both coding and non-coding regions of mitochondrial genomes, to each of the sample haplogroup and subhaplogroup affiliation was determined. Population of Macedonians represent quite typical European population, with highest frequency of haplogroup H (42.85%), followed by hg U (17.86%), T (11.43%), J (7.85%) and K(3.57%). The other, less frequent haplogoups, also take part in shaping the maternal genetic pool of this population. On the other hand Macedonian Romani, as an example of endogamous population of Indian origin, shows significant departure from haplogruop composition and frequencies when compared to Macedonians. The highest frequency represent M5a1 haplogroup (38.36%), untypical for any European population, but very common among Indian and Romany populations. Second most frequent haplogroup is hg H (22.64%), but only two haplotypes of hg H20 and H7a1 encompass one half of this haplogroup’s diversity. Hg X2 (mostly represented by X2e1), present with less than 1% in typical European population makes more than 10% of maternal gene pool of Macedonian Romany population. This data could have their potential role in human identification as an additional tool in forensic science community.

mitochondrial DNA; Macedonians; Macedonian Romani; haplogroup diversity; forensic identification

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