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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 635998

Časopis

Autori: Bulum, Tomislav; Kolarić, Branko; Prkačin, Ingrid; Duvnjak, Lea
Naslov: Hyperfiltration in normoalbuminuric type 1 diabetic patients : relationship with urinary albumin excretion rate
Izvornik: Collegium antropologicum (0350-6134) 37 (2013), 2; 471-476
Vrsta rada: članak
Ključne riječi: glomerular filtration rate; hyperfiltration; albuminuria; type 1 diabetes
Sažetak:
Hyperfiltration has been documented in type 1 diabetes and may contribute to the high risk for development of albuminuria and progression of nephropathy. However, recent studies suggest that the risk of progression to albuminuria in type 1 diabetes was not increased by hyperfiltration. We investigated associations of estimated glomerular filtration rate (eGFR) and urinary albumin excretion rate (UAE) in normoalbuminuric type 1 diabetic patients. Study included 313 normoalbuminuric patients with type 1 diabetes, none showed signs of adrenal, renal, or cardiovascular diseases. GFR was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Glomerular hyperfiltration was defined as eGFR ≥ 125 ml min-1 1.73m-2. Renal hyperfiltration was present in 12% of the study group. Subjects with eGFR ≥ 125 ml min-1 1.73m-2 were younger, had shorter duration of diabetes, lower levels of total and LDL cholesterol, and higher HbA1c than subjects with an eGFR below 125 ml min-1 1.73m-2. Type 1 diabetic patients with hyperfiltration also had significantly lower UAE. In a multiple logistic regression analysis, higher eGFR was associated with lower UAE. Our results indicate that normoalbuminuric type 1 diabetic patients with hyperfiltration have lower UAE than those with renal function in the normal range. Together with other recent studies this may suggest that creatinine-based estimates of GFR indicating hyperfiltration is not associated with higher UAE and subsequent development of microalbuminuria.
Projekt / tema: 045-1080230-0516
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
SCI-EXP, SSCI i/ili A&HCI
Current Contents Connect (CCC)
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
MEDLINE
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=153607
URL cjelovitog teksta:
Google Scholar: Hyperfiltration in normoalbuminuric type 1 diabetic patients : relationship with urinary albumin excretion rate
Upisao u CROSBI: Tomislav Bulum (tbulum@idb.hr), 6. Srp. 2013. u 11:12 sati



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