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Hyperbaric oxygen is effective in early stage of healing of experimental brain abscess in rats (CROSBI ID 194240)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bilić, Ivica ; Petri, Nadan ; Krstulja, Mira ; Vučković, Meri ; Salamunić, Ilza ; Kraljević Šiško, Katarina ; Čapkun, Vesna ; Lušić, Ivo Hyperbaric oxygen is effective in early stage of healing of experimental brain abscess in rats // Neurological research, 34 (2012), 10; 931-936. doi: 10.1179/1743132812Y.0000000091

Podaci o odgovornosti

Bilić, Ivica ; Petri, Nadan ; Krstulja, Mira ; Vučković, Meri ; Salamunić, Ilza ; Kraljević Šiško, Katarina ; Čapkun, Vesna ; Lušić, Ivo

engleski

Hyperbaric oxygen is effective in early stage of healing of experimental brain abscess in rats

Current therapy of brain abscess (BA) includes a combined approach that involves antibiotics and minimal invasive surgery, but also hyperbaric oxygen treatment (HBOT) as a supportive measure. Optimum treatment is still a matter of significant controversy. The experiment, previously approved by a relevant ethical commitee, involved 80 female Wistar rats. BA was experimentally induced by inoculation of Staphyloccocus aureus. The animals were randomized into groups and treated either with antibiotics, HBOT, or with a combination of both. Beneficial effect of HBOT was evident in groups treated with HBOT or with a combination of antibiotic + HBOT. It was mainly manifested on days three and five of the experiment and was evident as statistically significant increase of a number of newly formed blood vessels, increase in mean vascular density, and smaler abscess necrotic core. Althought the results of the present study should be interpreted cautiously, they suggest that HBOT has an important but limited role in the treatment of BA.

brain abscess; experimental model; healing; hyperbaric oxygen; neoangiogenesis; Staphyloccocus aureus

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Podaci o izdanju

34 (10)

2012.

931-936

objavljeno

0161-6412

10.1179/1743132812Y.0000000091

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

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