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Association of hsp70-2 (+1267A/G) and hsp70-hom (+2437T/C) polymorphisms with cerebral atherosclerosis in Croatian population

The aim of this study was to test for a possible association of hsp70- 2 (+1267A/G) and hsp70-hom (+2437T/C) polymorphisms with ste- nosis of cerebral arteries (SCA) in the Croatian population. The genotyping of DNA, isolated from the whole blood of 51 patients with SCA and 48 healthy controls, was performed. Frag- ment size analysis upon restriction enzyme digestion was used for genotype/allele definition. The significance of findings was tested using the v2 test. hsp70-2 (+1267A/G) polymorphism was associated signifi- cantly with SCA. The results of genotyping analysis indicated that the genotype AG was associated preferentially with SCA (p = 0.039). No association for hsp70-hom (+2437T/C) polymor- phism was found. The study results support the existence of an association of hsp70- 2 (+1267A/G) polymorphism with cerebral atherosclerosis. A higher frequency of the AG genotype in Croatian patients was observed. There was no evidence for an association of hsp70-hom (+2437T/C) polymorphism with cerebral atherosclerosis.

hsp70-hom; hsp70-2; stenosis of cerebral arteries (SCA); Croatian population; SNP

DOI: 10.1111/febs.12340