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izvor podataka: crosbi

Extensive polymorphism of the major histocompatibility complex DRA gene in Balkan donkeys: perspectives on selection and genealogy (CROSBI ID 195012)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Arbanasić, Haidi ; Galov, Ana ; Ambriović-Ristov, Andreja ; Grizelj, Juraj ; Arsenos, Georgios ; Marković, Božidarka ; Dovenski, Toni ; Vince, Silvijo ; Čurik, Ino Extensive polymorphism of the major histocompatibility complex DRA gene in Balkan donkeys: perspectives on selection and genealogy // Animal genetics, 44 (2013), 6; 711-716. doi: 10.1111/age.12054

Podaci o odgovornosti

Arbanasić, Haidi ; Galov, Ana ; Ambriović-Ristov, Andreja ; Grizelj, Juraj ; Arsenos, Georgios ; Marković, Božidarka ; Dovenski, Toni ; Vince, Silvijo ; Čurik, Ino

engleski

Extensive polymorphism of the major histocompatibility complex DRA gene in Balkan donkeys: perspectives on selection and genealogy

The major histocompatibility complex (MHC) contains genes important for immune response in mammals, and these genes exhibit high polymorphism and diversity. The DRA gene, a member of the MHC class II family, is highly conserved across a large number of mammalian species, but it displays exceptionally rich sequence variations in Equidae members. We analyzed allelic polymorphism of the DRA locus in 248 donkeys sampled across the Balkan Peninsula (Albania, Bulgaria, Croatia, Macedonia, Greece and Montenegro). Five known alleles and two new alleles were identified. The new allele Eqas-DRA*0601 was found to carry a synonymous mutation, and new allele Eqas-DRA*0701, a non-synonymous mutation. We further analyzed the historical selection and allele genealogy at the DRA locus in equids. Signals of positive selection obtained by various tests were ambiguous. A conservative conclusion is that DRA polymorphism occurred relatively recently and that positive selection has been acting on the DRA locus for a relatively brief period.

donkey; DRA locus; genetic diversity; major histocompatibility complex; selection

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Podaci o izdanju

44 (6)

2013.

711-716

objavljeno

0268-9146

10.1111/age.12054

Povezanost rada

Veterinarska medicina, Poljoprivreda (agronomija), Biologija

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