Paraoxonase polymorphism in cardiovascular diseases (CAD) (CROSBI ID 479534)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Ivanišević, Ana-Maria ; Štefanović, Mario ; Topić, Elizabeta ; Nikolić, Vjeran ; Petrač, Dubravko ; Čubrilo-Turek, Mirjana
engleski
Paraoxonase polymorphism in cardiovascular diseases (CAD)
Paraoxonase (PON1) genetic polymorphism at codon 192 (glutamine to arginine substitution, genotypes A and B, respectively) has been shown to affect the risk of CVD. The aim of this study was to genotype 44 controls and 100 CVD patients with different diagnosis (coronary artery disease (CAD), myocardial infarction (MI), hypertension and carotid stenosis (CS)) by PCR-RFLP using Alw1 restriction enzyme. Study results showed that out of 44 controls 18/44 (40.9%) were A and 1/44 (2.3%) B homozygotes and 25/44 (56.8%) heterozygotes. Among 31 CAD patients 9/31 (29.0%) were A and 5/31 (16.1%) B homozygotes and 17/31 (54.8%) heterozygotes. In 27 MI patients 8/27 (29.6%) were A and 4/27 (14.8%) B homozygotes and 15/27 (55.6%) heterozygotes. Out of 16 hypertension patients 6/16 (37.5%) were A and 3/16 (18.8%) B homozygotes and 7/16 (43.8%) heterozygotes. Among 26 CS patients 15/26 (57.7%) were A and 2/26 (7.7%) B homozygotes and 9/26 (34.6%) heterozygotes. Genotypes between controls and patients differed significantly (Chi-square test ; P=0.002, 0.003, <0.001 and 0.003 ; for CAD, MI, Hypertension and CS patients, respectively). Allelic frequencies did not differ significantly between controls and patients. Our findings indicate the association between the codon 192 polymorphism of PON1 gene and cardiovascular diseases.
PON1 gene; cardiovascular diseases
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
131-132-x.
1999.
objavljeno
Podaci o matičnoj publikaciji
European Journal of Human Genetics : Programme and abstracts
Van Ommen, Gert-Jan B.
Hampshire: Stockton Press
Podaci o skupu
31st Annual Meeting of the European Society for Human Genetics
poster
29.05.1999-01.06.1999
Ženeva, Švicarska