Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling (CROSBI ID 195062)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Car, Željka ; Hrenar, Tomica ; Petrović Peroković, Vesna ; Ribić, Rosana ; Seničar, Mateja ; Tomić, Srđanka Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling // Chemical biology & drug design, 84 (2014), 393-401. doi: 10.1111/cbdd.12329

Podaci o odgovornosti

Car, Željka ; Hrenar, Tomica ; Petrović Peroković, Vesna ; Ribić, Rosana ; Seničar, Mateja ; Tomić, Srđanka

engleski

Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling

Structural alterations of the aglycon portions of amannosides influence their inhibitory potency toward type 1-fimbriated Escherichia coli. The aim of our work was to prepare and explore inhibitory properties of novel mannosylated N-aryl-substituted 3- hydroxypyridine-4-ones because they possess needed structural characteristics as possible FimH antagonists. Hemagglutination inhibitory tests showed that the examined 3- hydroxypyridine-4-one a-mannosides exhibited better inhibitory activity than methyl a-D- mannopyranoside used as a reference compound. Molecular modeling studies revealed the specific interactions responsible for the observed binding activities toward the mannosespecific FimH lectin. The activity depends on the substituent in p-position on the aglycon aromatic ring.

Escherichia coli; FimH lectin; hemagglutination; molecular modeling; N-aryl-substituted 3-hydroxypyridine-4- ones; a-mannopyranosides

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

84

2014.

393-401

objavljeno

1747-0277

10.1111/cbdd.12329

Povezanost rada

Kemija

Poveznice
Indeksiranost