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izvor podataka: crosbi

Restricted spatiotemporal expression of lactoferrin during murine embryonic development (CROSBI ID 195250)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ward, P.P. ; Mendoza-Meneses, M. ; Mulac-Jeričević, Biserka ; Cunningham, G.A. ; Saucedo-Cardenas, O. ; Teng, C.T. ; Conneely, O.M. Restricted spatiotemporal expression of lactoferrin during murine embryonic development // Endocrinology, 140 (1999), 4; 1852-1860

Podaci o odgovornosti

Ward, P.P. ; Mendoza-Meneses, M. ; Mulac-Jeričević, Biserka ; Cunningham, G.A. ; Saucedo-Cardenas, O. ; Teng, C.T. ; Conneely, O.M.

engleski

Restricted spatiotemporal expression of lactoferrin during murine embryonic development

Lactoferrin is a member of the transferrin family of iron-binding glycoproteins. Lactoferrin is induced by estrogen in the mouse uterus during early pregnancy. However, the expression and function, if any, of lactoferrin in the preimplantation embryo during this developmental period has not been investigated. In the current study, the spatiotemporal expression of lactoferrin during murine embryogenesis was examined using in situ hybridization and immunohistochemical analyses. Lactoferrin expression was first detected in the 2-4 cell fertilized embryo and continued until the blastocyst stage of development. Interestingly, at the 16-cell stage, coinciding with the first major differentiation step in the embryo, lactoferrin messenger RNA (mRNA) is synthesized by the inner cells, whereas the protein is selectively taken up by the outside cells. This differential pattern of lactoferrin messenger RNA and protein localization continues until the blastocyst stage, with expression almost absent in the hatched blastocyst. Lactoferrin expression does not resume in the embryo until the latter half of gestation, where it is first detected in neutrophils of the fetal liver at embryonic day 11.5 and later in epithelial cells of the respiratory and digestive systems. Our results show that lactoferrin is expressed in a tightly regulated spatiotemporal manner during murine embryogenesis and suggest a novel paracrine role for this protein in the development of the trophoectodermal lineage during preimplantation development

estrogen receptor; implantation; lactoferrin;

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

140 (4)

1999.

1852-1860

objavljeno

0013-7227

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost