engleski

Blood pressure is associated with gamma- glutamyltransferase and alkaline phosphatase in normoalbuminuric type 1 diabetic patients

Nonalcoholic fatty liver disease (NAFLD) is more often in non-diabetic subjects with primary hypertension. Moreover, it has been documented that markers of NAFLD, γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) are associated with hypertension, coronary artery disease, left ventricular diastolic dysfunction, and with progressive arterial calcification in patients with advanced chronic kidney disease. The aim of this study was to explore the relationship between markers of NAFLD, namely concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, GGT, and bilirubin with blood pressure in type 1 diabetic patients with normal renal function. GGT and ALP significantly correlated with systolic (r=0.13 and 0.12, p<0.05) and diastolic blood pressure (r=0.11 and 0.16, p<0.05). Correlation between AST, ALT and bilirubin with systolic (r=0.06, 0.09 and 0.08) and diastolic blood pressure (r=-0.05, 0.02 and 0.03) was not statistically significant. In this study of type 1 diabetic patients we have shown that the markers of NAFLD, ALP and GGT, are positively associated with systolic and diastolic blood pressure. Higher ALP and GGT can be an additional marker of hypertension in type 1 diabetic patients indicating that those subjects are not only at risk of hepatic disease, but also at risk of coronary artery disease and progression of renal disease.

blood pressure; gamma-glutamyltransferase; alkaline phosphatase; type 1 diabetes

nije evidentirano