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Diastolic blood pressure is associated with albuminuria in normoalbuminuric type 1 diabetic patients

Diabetes mellitus is the major cause of end-stage kidney disease, and hypertension is one of the main determinants of progression of renal disease. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) are a risk factors for the development of microalbuminuria in nondiabetic population. The aim of this study was to explore the relationship between systolic and diastolic blood pressure and markers of renal function (serum creatinine, estimated glomerular filtration rate (eGFR) and urinary albumin excretion (UAE)) in normoalbuminuric type 1 diabetic patients. Diastolic blood pressure significantly correlated only with UAE (r=0.23, p<0.001). Correlation between serum creatinine and eGFR with systolic (r=0.10 and -0.08) and diastolic blood pressure (r=0.08 and -0.01) was not statistically significant. Many studies have demonstrated that strict control of hypertension significantly reduces the incidence and progression of diabetic kidney disease. In this study we have shown that diastolic blood pressure elevation in normoalbuminuric type 1 diabetic patients may be associated with higher UAE and progression of diabetic nephropathy.

blood pressure; albuminuria; type 1 diabetes

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