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Pregled bibliografske jedinice broj: 642115

Časopis

Autori: Štefulj, Jasminka; Panzenboeck, Ute; Hof, Patrick R; Šimić, Goran
Naslov: Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors
Izvornik: Translational Neuroscience (2081-3856) 4 (2013), 3; 349-356
Vrsta rada: pregledni rad
Ključne riječi: Alzheimer’s disease; neurodegeneration; Amyloid-beta; cholesterol; liver-X receptors; LXR agonists; neuroinflammation; Transgenic mouse models
Sažetak:
The pathogenesis of Alzheimer’s disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.
Projekt / tema: HRZZ-09/16, 098-1081870-2395, 108-1081870-1942
Izvorni jezik: ENG
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
Web of Science: Science Citation Index Expanded
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti
Puni text rada: 642115.Stefulj2013TN.pdf (tekst priložen 16. Ruj. 2013. u 12:40 sati)
URL Internet adrese: http://www.degruyter.com/view/j/tnsci.2013.4.issue-3/s13380-013-0136-z/s13380-013-0136-z.xml?rskey=VvH39F&result=1
http://fulir.irb.hr/3049/1/Stefulj_Jasminka_et_al-2013-Translational_neuroscience-Pathogenesis_modulation_and_therapy_of_alzheimers_disease.pdf
Broj citata:
Altmetric:
DOI: 10.2478/s13380-013-0136-z
URL cjelovitog teksta:
Google Scholar: Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors
Upisao u CROSBI: Jasminka Štefulj (Jasminka.Stefulj@irb.hr), 16. Ruj. 2013. u 12:40 sati



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