Aging-related expression of various transporters in rat kidneys (CROSBI ID 599890)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Sabolić, Ivan ; Breljak, Davorka ; Micek, Vedran ; Herak-Kramberger, Carol M. ; Karaica, Dean ; Ljubojević, Marija ; Vrhovac, Ivana ; Rašić, Dubravka ; Peraica, Maja ; Sekovanić, Ankica ; Jurasović, Jasna ; Anzai, Naohiko ; Koepsell, Hermann
engleski
Aging-related expression of various transporters in rat kidneys
Aging is an inevitable physiological process characterized by a gradual decline in the functional capabilities regarding personal and environmental needs. In the absence of underlying diseases that accelerate aging (diabetes, cancer, etc…), kidneys are crucial organs for „healthy aging“. Aging kidneys exhibit functional, structural, and genomic losses. The impaired secretory and reabsorptive functions in handling water, organic compounds, drugs, toxins, and the increased tendency to drug-drug interactions, drug-induced adverse reactions, and drug (nephro)toxicity indicate that aging affects various renal transporters, but relevant studies on their activity and/or expression are missing. To initiate such studies, we compared various biochemical, immunochemical, and mRNA parameters in young (Y ; 3 months old) and old (O ; 2 years old) male rats. In comparison with Y, the O rats had higher body mass, lower blood testosterone, lower urine flow and excretion of inorganic ions, and unchanged excretion of glucose. The O rats exhibited lower expression of organic anion (Oat1, Oat3) and cation (Oct1, Oct2) transporters, Na+-phosphate cotransporter NaPi2, and water channel AQP1. The expression of Na/K-ATPase, Oat2, Oat5, Na+-glucose cotransporters (Sglt1, Sglt2), and AQP2 was similar in Y and O rats. We concluded that aging in rats selectively downregulates the renal transporters that are androgen-dependent.
Aging; renal transporters; rat
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Podaci o prilogu
51-x.
2013.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Periodicum biologorum
Vitale, Branko
Zagreb: Hrvatsko prirodoslovno društvo ; Institut Ruđer Bošković ; Laser Plus
0031-5362
Podaci o skupu
3. Congress of Croatian Physiological Society and 1. Regional Congress of the Physiological Societies
pozvano predavanje
13.09.2013-15.09.2013
Rijeka, Hrvatska
Povezanost rada
Temeljne medicinske znanosti