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Aging-related expression of various transporters in rat kidneys (CROSBI ID 599890)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija

Sabolić, Ivan ; Breljak, Davorka ; Micek, Vedran ; Herak-Kramberger, Carol M. ; Karaica, Dean ; Ljubojević, Marija ; Vrhovac, Ivana ; Rašić, Dubravka ; Peraica, Maja ; Sekovanić, Ankica et al. Aging-related expression of various transporters in rat kidneys // Periodicum biologorum / Vitale, Branko (ur.). 2013. str. 51-x

Podaci o odgovornosti

Sabolić, Ivan ; Breljak, Davorka ; Micek, Vedran ; Herak-Kramberger, Carol M. ; Karaica, Dean ; Ljubojević, Marija ; Vrhovac, Ivana ; Rašić, Dubravka ; Peraica, Maja ; Sekovanić, Ankica ; Jurasović, Jasna ; Anzai, Naohiko ; Koepsell, Hermann

engleski

Aging-related expression of various transporters in rat kidneys

Aging is an inevitable physiological process characterized by a gradual decline in the functional capabilities regarding personal and environmental needs. In the absence of underlying diseases that accelerate aging (diabetes, cancer, etc…), kidneys are crucial organs for „healthy aging“. Aging kidneys exhibit functional, structural, and genomic losses. The impaired secretory and reabsorptive functions in handling water, organic compounds, drugs, toxins, and the increased tendency to drug-drug interactions, drug-induced adverse reactions, and drug (nephro)toxicity indicate that aging affects various renal transporters, but relevant studies on their activity and/or expression are missing. To initiate such studies, we compared various biochemical, immunochemical, and mRNA parameters in young (Y ; 3 months old) and old (O ; 2 years old) male rats. In comparison with Y, the O rats had higher body mass, lower blood testosterone, lower urine flow and excretion of inorganic ions, and unchanged excretion of glucose. The O rats exhibited lower expression of organic anion (Oat1, Oat3) and cation (Oct1, Oct2) transporters, Na+-phosphate cotransporter NaPi2, and water channel AQP1. The expression of Na/K-ATPase, Oat2, Oat5, Na+-glucose cotransporters (Sglt1, Sglt2), and AQP2 was similar in Y and O rats. We concluded that aging in rats selectively downregulates the renal transporters that are androgen-dependent.

Aging; renal transporters; rat

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Podaci o prilogu

51-x.

2013.

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objavljeno

Podaci o matičnoj publikaciji

Periodicum biologorum

Vitale, Branko

Zagreb: Hrvatsko prirodoslovno društvo ; Institut Ruđer Bošković ; Laser Plus

0031-5362

Podaci o skupu

3. Congress of Croatian Physiological Society and 1. Regional Congress of the Physiological Societies

pozvano predavanje

13.09.2013-15.09.2013

Rijeka, Hrvatska

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost