crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 643212

Zbornik radova

Autori: Bulum, Tomislav; Blaslov, Kristina; Zibar, Karin; Duvnjak, Lea
Naslov: Alkaline phosphatase is independently associated with renal function in normoalbuminuric type 1 diabetic patients
Izvornik: Diabetologia 2013 ; 56 (Suppl. 1): S476-S477
ISSN: 0012-186X
Skup: 49th EASD Annual Meeting
Mjesto i datum: Barcelona, Španjolska, 23.09.-27.09.2013.
Ključne riječi: type 1 diabetes; renal function; nonalcoholic fatty liver disease
Sažetak:
Nonalcoholic fatty liver disease (NAFLD) is associated with an increased prevalence of chronic kidney disease. The aim of this study was to explore the relationship between markers of NAFLD and renal function in normoalbuminuric type 1 diabetic patients. This study included 313 normoalbuminuric type 1 diabetic patients with estimated glomerular filtration rate (eGFR) > 60 mlmin-11.73m-2, without clinical evidence of cirrhosis or other causes of chronic liver disease and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. ALT, GGT, bilirubin and ferritin levels were significantly higher in subjects in the highest quartile of serum creatinine compared to those in lowest quartile (21 vs 20 U/L, 18 vs 14 U/L, 14 vs 10 µmol/L, and 103 vs 25 µg/L, respectively, for all p<0.05). ALK levels were significantly higher in subjects in the highest quartile of urinary albumin excretion rate compared to those in lowest quartile (71 vs 69 U/L, p=0.03), as well as in hyperfiltrating subjects compared to those with normal or mildly impaired eGFR (81 vs 68 and 64 U/L, p<0.001). In a multiple logistic regression model only ALK levels were significantly associated with disturbances in serum creatinine and eGFR in our subjects (p≤0.007), with odds ratios of 0.98 to 1.02. This study, conducted in normoalbuminuric type 1 diabetic patients with normal or mildly impaired renal function and with no therapeutic intervention, suggest that ALK may play a role in the pathogenesis of renal impairment in type 1 diabetic patients.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 045-1080230-0516
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Upisao u CROSBI: Tomislav Bulum (tbulum@idb.hr), 23. Ruj. 2013. u 20:53 sati



Verzija za printanje   za tiskati


upomoc
foot_4