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TRACE ELEMENTS DYSHOMEOSTASIS INDUCED BY EXPOSURE OF MICE TO GASOLINE VAPOR AND STRESS (CROSBI ID 600161)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija

Milin, Čedomila ; Tota, Marin ; Grebić, Damir ; Jakovac, Hrvoje ; Broznić, Dalibor ; Marinić, Jelena ; Čanadi Jurešić, Gordana ; Radošević-Stašić, Biserka TRACE ELEMENTS DYSHOMEOSTASIS INDUCED BY EXPOSURE OF MICE TO GASOLINE VAPOR AND STRESS // Journal of Medical Biochemistry / Danev, Stoyan ; Shipkov, Todor ; Svinarov, Dobrin A (ur.). 2013. str. 148-148

Podaci o odgovornosti

Milin, Čedomila ; Tota, Marin ; Grebić, Damir ; Jakovac, Hrvoje ; Broznić, Dalibor ; Marinić, Jelena ; Čanadi Jurešić, Gordana ; Radošević-Stašić, Biserka

engleski

TRACE ELEMENTS DYSHOMEOSTASIS INDUCED BY EXPOSURE OF MICE TO GASOLINE VAPOR AND STRESS

To investigate the effects of air pollution related with gasoline/petrochemical industry the expression of metallothionein I (MT-I) mRNA and tissue metals were analyzed in organs of mice, exposed to the gasoline (G) vapor in laboratory conditions. Control groups consisted of intact mice and of those exposed in the metabolic chamber to fresh air. The data obtained by RT-PCR and inductively coupled plasma spectrometry have shown that exposure to G vapor leads to upregulation of MT-I mRNA in organs that receive a strong respiratory and olfactory input or participate in gasoline degradation and elimination (lungs, brain, kidney and liver). Simultaneously, the tissue content of Zn2+ decreased in the brain and the concentration of Cu2+ and Mg2+ in the brain, lungs, kidney and liver (p<0.001). Some of these changes were found also in mice closed in the metabolic chamber, pointing to the involvement of stress-induced mechanisms in the transcriptional regulation of MTs.

Gasoline inhalation; Stress; Metallothioneins I; Zinc; Copper; Magnesium; Brain; Lungs; Kidney; Liver

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Podaci o prilogu

148-148.

2013.

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objavljeno

Podaci o matičnoj publikaciji

Journal of Medical Biochemistry

Danev, Stoyan ; Shipkov, Todor ; Svinarov, Dobrin A

Budva: Balkan Clinical Laboratory Federation (Montenegrian Association)

1452-8258

Podaci o skupu

21st Meeting of Balkan Clinical Laboratory Federation

poster

25.09.2013-28.09.2013

Budva, Crna Gora

Povezanost rada

Kemija, Temeljne medicinske znanosti

Indeksiranost