TRACE ELEMENTS DYSHOMEOSTASIS INDUCED BY EXPOSURE OF MICE TO GASOLINE VAPOR AND STRESS (CROSBI ID 600161)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Milin, Čedomila ; Tota, Marin ; Grebić, Damir ; Jakovac, Hrvoje ; Broznić, Dalibor ; Marinić, Jelena ; Čanadi Jurešić, Gordana ; Radošević-Stašić, Biserka
engleski
TRACE ELEMENTS DYSHOMEOSTASIS INDUCED BY EXPOSURE OF MICE TO GASOLINE VAPOR AND STRESS
To investigate the effects of air pollution related with gasoline/petrochemical industry the expression of metallothionein I (MT-I) mRNA and tissue metals were analyzed in organs of mice, exposed to the gasoline (G) vapor in laboratory conditions. Control groups consisted of intact mice and of those exposed in the metabolic chamber to fresh air. The data obtained by RT-PCR and inductively coupled plasma spectrometry have shown that exposure to G vapor leads to upregulation of MT-I mRNA in organs that receive a strong respiratory and olfactory input or participate in gasoline degradation and elimination (lungs, brain, kidney and liver). Simultaneously, the tissue content of Zn2+ decreased in the brain and the concentration of Cu2+ and Mg2+ in the brain, lungs, kidney and liver (p<0.001). Some of these changes were found also in mice closed in the metabolic chamber, pointing to the involvement of stress-induced mechanisms in the transcriptional regulation of MTs.
Gasoline inhalation; Stress; Metallothioneins I; Zinc; Copper; Magnesium; Brain; Lungs; Kidney; Liver
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
148-148.
2013.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Journal of Medical Biochemistry
Danev, Stoyan ; Shipkov, Todor ; Svinarov, Dobrin A
Budva: Balkan Clinical Laboratory Federation (Montenegrian Association)
1452-8258
Podaci o skupu
21st Meeting of Balkan Clinical Laboratory Federation
poster
25.09.2013-28.09.2013
Budva, Crna Gora
Povezanost rada
Kemija, Temeljne medicinske znanosti