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Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentrations (CROSBI ID 196545)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Zgaga, Lina ; Vitart, Veronique ; Hayward, Caroline ; Kaštelan, Darko ; Polašek, Ozren ; Jakovljević, Miro ; Kolčić, Ivana ; Biloglav, Zrinka ; Wright, Alan F ; Campbell, Harry et al. Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentrations // European journal of endocrinology, 169 (2013), 59-64. doi: 10.1530/EJE-12-0916

Podaci o odgovornosti

Zgaga, Lina ; Vitart, Veronique ; Hayward, Caroline ; Kaštelan, Darko ; Polašek, Ozren ; Jakovljević, Miro ; Kolčić, Ivana ; Biloglav, Zrinka ; Wright, Alan F ; Campbell, Harry ; Walker, Brian R. ; Rudan, Igor

engleski

Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentrations

Stress is implicated as a risk factor for numerous illnesses in humans, putatively in part mediated by biological responses to stress, such as elevated cortisol concentrations. The theory of genetic homoeostasis suggests that individual heterozygosity facilitates compensation for environmental stresses. We hypothesized that heterozygosity ameliorates the biological response to a given level of perceived stress, reflected in lower plasma cortisol concentrations. DESIGN: We examined the role of heterozygosity in the association between perceived psychological stress and morning cortisol concentrations in 854 individuals from the isolated island of Vis, Croatia. Cortisol concentrations were measured in morning plasma samples. A total of 1184 autosomal microsatellite markers were genotyped and individual multi-locus heterozygosity (MLH) was calculated as the proportion of heterozygous markers. The General Health Questionnaire with 30 items (GHQ-30) was used to assess the degree of psychological distress. MEAN MLH WAS 34.850.45% (RANGE: 31.97-36.22%). Psychological distress (GHQ Likert score >31) was more prevalent in women (37 vs 18% in men, P<0.0001), in less educated people (β=-0.35 per year in school, P<0.001) and in lower socio-economic classes (β=-3.59, P<0.0001). Cortisol concentrations were positively associated with psychological distress (β=2.20, P=0.01). In a regression model adjusted for age, BMI, education and GHQ-30 score, MLH was independently and inversely associated with morning plasma cortisol concentrations (P=0.005). More heterozygous individuals, as measured by microsatellite markers, had lower morning plasma cortisol concentrations for a given level of perceived psychological stress. This may be important, as higher cortisol concentrations may increase the allostatic load and be associated with a higher risk of stress-related illness.

stress; cortisol; individual multi-locus heterozygosity

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

169

2013.

59-64

objavljeno

0804-4643

10.1530/EJE-12-0916

Povezanost rada

Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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