The role of anesthetics in the phrenic long term facilitation in rats (CROSBI ID 601253)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Pecotić, Renata ; Valić, Maja ; Pavlinac Dodig, Ivana ; Carev, Mladen ; Karanović, Nenad ; Valić, Zoran ; Đogaš, Zoran
engleski
The role of anesthetics in the phrenic long term facilitation in rats
Long term facilitation is a form of respiratory plasticity that is induced following exposures to the repeated episodes of intermittent hypoxia. It represents one of the most studied model of respiratory plasticity and a model of obstructive sleep apnea as well. A variety of different variables could affect manifestation of LTF and the choice of anesthetic might have a great impact. Over the past 30 years in an animal model of paralyzed, bilaterally vagotomized, mechanically ventilated rats, urethane was used as an anesthetic of choice because of its minimal effects on respiratory, cardiovascular, and autonomic nervous system. Adult, male, anesthetized, bilaterally vagotomized, paralyzed and mechanically ventilated Sprague Dawley rats were exposed to an acute intermittent hypoxia (AIH) protocol consisting of 5 hypoxic exposures (9% O2 in air) lasting for 3 min each, separated by hyperoxic (50% O2 in air) 3 minutes periods. Peak phrenic nerve activity, respiratory frequency, and respiratory rhythm parameters were analyzed during hypoxia, as well as at 15, 30, and 60 min after the end of the last hypoxic episode. We investigated effects of volatile anesthetics (sevoflurane and isoflurane), opioid anesthetics (remifentanil) and propofol on the manifestation of phrenic LTF and on hypoxic ventilatory response. Results of our research do highlight the potential caveats that might be associated with the selection of a given anesthetic regime to examine phrenic LTF.
long term facilitation; intermittent hypoxia; reamifentanil; phrenic nerve; opioids
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Podaci o prilogu
2013.
objavljeno
Podaci o matičnoj publikaciji
abstracts of the 4th Croatian Neuroscience Congress
Podaci o skupu
Croatian Neuroscience Congress (4 ; 2013)
poster
20.09.2013-21.09.2013
Zagreb, Hrvatska