Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD (CROSBI ID 196615)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Žuntar, Irena ; Petlevski, Roberta ; Dodig, Slavica ; Popović-Grle, Sanja GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD // Acta pharmaceutica, 64 (2014), 117-129. doi: 10.2478/acph-2014-0003

Podaci o odgovornosti

Žuntar, Irena ; Petlevski, Roberta ; Dodig, Slavica ; Popović-Grle, Sanja

engleski

GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD

The aim of this study was to test the hypothesis that glutathione-S-transferase (GST) genotypes were associated with COPD. GSTP1, GSTM1 and GSTT1 genotypes were determined by DNA methods and GST activity spectrophotometrically in older male Caucasian Croats (non-smokers, ex-smokers, and smokers) with stable COPD (n=30) and sex/age matched controls (n=60). The distribution of GSTP1 genotypes and alleles in controls vs. COPD showed statistical difference (p<0.05). The odds ratio of CC/CT+TT (wild type GSTP1 exon 6 vs. joint heterozygous and mutant homozygous GSTP1 exon 6) was 10.000 and statistically different (p=0.002). By this study, the GSTP1 mutant genotype of exon 5 (GG), and also GSTP1 mutant and heterozygous genotypes of exon 6 (TT and CT) were suggested to be a genetic contributors to COPD susceptibility. Null GSTM1, null GSTT1 and the joint GSTM1/GSTT1 null genotypes were not disease-associated. Serum GST was not associated with GST genotypes and COPD as well as smoking history in our study subjects. Conclusions reviled from the study should be furthermore supported and clarified by studies with larger sample sizes.

glutathione S-transferases (GST); polymorphism; COPD; alpha-1-antitrypsin; lactate dehydrogenase

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

64

2014.

117-129

objavljeno

1330-0075

10.2478/acph-2014-0003

Povezanost rada

Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija

Poveznice
Indeksiranost