Glycols in toothpaste on Croatian market (CROSBI ID 601327)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Vidić Štrac, Ivona ; Žuntar, Irena ; Dimitrov, Nino ; Puklek, Maja
engleski
Glycols in toothpaste on Croatian market
Diethylene Glycol (DEG) (CAS 111-46-6) is a highly toxic organic solvent that may cause nausea, dizziness, kidney failure, breathing problems, convulsions and even coma when ingested. The potential health risks from chronic exposure to DEG are a particular concern in specific vulnerable populations such as children and consumers with kidney or liver disease. DEG is forbidden as cosmetic ingredient but can be present as an impurity in glycerol and polyethylene glycols, common ingredients in oral care products. Maximum permitted concentration as impurity is 0.1%m/m. The objective of this study was to determine the presence of diethylene glycol in toothpaste on the Croatian market using a gas chromatography–mass spectrometry method. Linearity of the response of mass detector was tested by analyzing standard solutions with increasing concentrations of monoethylene glycol and diethylene glycol. Regression analysis of chromatographic data indicates that linearity of response in the detector was within the examined concentration area 0.5-50mg/L, with correlation coefficients >0.998. Limit of detection (LOD) for DEG was <6mg/kg, and for MEG <4mg/kg. Testing was conducted on 30 samples of toothpaste produced and marketed in Croatia and EU. Obtained results were significantly below the permitted threshold of 0.1% thus assuring consumer safety.
diethylene glycol ; gas chromatography - mass spectrometry ; limit of detection ; maximum permitted concentration ; monoethylene gycol ; oral care product
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Podaci o prilogu
66-66.
2012.
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objavljeno
Podaci o matičnoj publikaciji
Arhiv za higijenu rada i toksikologiju
Kopjar, Nevenka
Zagreb: Institute for Medical Research and Occupational Health, Zagreb, Croatia
0004-1254
Podaci o skupu
4th Croatian Congress of Toxicology with international participation
poster
02.10.2012-05.10.2012
Primošten, Hrvatska
Povezanost rada
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija