engleski

Adenovirus Respiratory Infections in Hospitalized Children Clinical Findings in Relation to Species and Serotypes

There are >50 adenovirus (AD V) serotypes that are divided into 7 species (A–G). The aim of this study was to characterize AD V serotypes and species in hospitalized infants and children in the City of Zagreb and Zagreb County and to describe clinical features and laboratory findings of AD V infections according to the causative AD V serotype. During the 3-year period from January 2006 to November 2008, 135 children (<10 years of age) with AD V respiratory infection, based on virus isolation, were treated at 2 hospitals in Zagreb. Demographics, clinical presentations and laboratory findings were evaluated. Of the 135 AD V isolates, 77 (57.0%) were type 2, followed by 26 (19.3%) of type 1, 15 (11.1%) isolates of type 3, 2 (1.5%) of type 6 and only 1 (0.7%) was type 7. Male-to-female ratio was 3.2:1 (103 boys and 32 girls). The mean age was 22.9 months. The most common symptoms were fever (98%), rhinorrhea (89%) and cough (71%). The mean peak body temperature was 39.8°C. Tonsillitis was present in 79 (59%) and acute otitis media in 37 (28%) patients. Leukocytosis (>15.0 × 109/L) was noted in 103 (77%) patients. Serum C-reactive protein was >40 mg/L in 74 patients (56%). The erythrocyte sedimentation rate was 30 mm/h in 91 (71%) of the 127 patients tested. In this study, the most common isolated serotype was AD V type 2. Most affected children were younger than 3 years. AD V infections in young children can present with prolonged fever, leukocytosis and significantly elevated C-reactive protein and erythrocyte sedimentation rate, mimicking bacterial infections.

adenovirus; serotype; respiratory viral infection; children

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