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In vitro inhibition of blood cholinesterase activities from cattle by triazole fungicides (CROSBI ID 197656)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Kolesárová, Viera ; Šinko, Goran ; Šiviková, Katarína ; Dianovský, Ján In vitro inhibition of blood cholinesterase activities from cattle by triazole fungicides // Caryologia, 66 (2013), 4; 346-350. doi: 10.1080/00087114.2013.855390

Podaci o odgovornosti

Kolesárová, Viera ; Šinko, Goran ; Šiviková, Katarína ; Dianovský, Ján

engleski

In vitro inhibition of blood cholinesterase activities from cattle by triazole fungicides

The changes in cattle acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities after exposure to tebuconazole-based fungicides (Orius and Prosaro®) in vitro were determined spectrophotometrically according to the Ellman method. The fungicides induced the decrease in AChE and BChE levels in a dose-dependent manner. Statistically significant inhibition of erythrocyte AChE levels was observed in the concentration range from 150 to 300 μg ml−1 (p < 0.001) for Orius and from 100 to 300 μg ml−1 for Prosaro® (p < 0.01 and p < 0.001, respectively). Levels of BChE activity were more reduced for the fungicide Orius (40–50%) than for Prosaro®. Statistical significance in the inhibition of BChE activity was found after exposure of cattle plasma to both fungicides at concentrations starting from 150 μg ml−1 (p < 0.001). Our results indicate that tebuconazole-based fungicides are able to reduce cattle AChE and BChE activities.

cattle; cholinesterase; exposure; inhibition; tebuconazole-based fungicides

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Podaci o izdanju

66 (4)

2013.

346-350

objavljeno

0008-7114

10.1080/00087114.2013.855390

Povezanost rada

Kemija, Veterinarska medicina

Poveznice
Indeksiranost