Photoelectron spectroscopy of non-steroidal anti-inflammatory drugs (CROSBI ID 197853)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Novak, Igor ; Klasinc, Leo ; Chong, Delanopun ; McGlynn, Séan P.
engleski
Photoelectron spectroscopy of non-steroidal anti-inflammatory drugs
The electronic structures of eight non-steroidal anti-inflammatory drugs (NSAIDs) had been studied by UV photoelectron spectroscopy (UPS) and high-level Green's function (GF) calculations. Our UPS data show that the electronic structure influences the measured biological activity of NSAID, but that it is not the dominating factor. The role of electronic structure needs to be considered in conjunction with other factors like steric properties of the COX active site and orientation of relevant residues in the same site
biological activity ; non-steroidal anti-inflammatory drugs ; photoelectron spectroscopy
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Podaci o izdanju
112
2013.
110-115
objavljeno
1386-1425
10.1016/j.saa.2013.04.012