BMP-7 induced osteogenesis in partial calvarial bone defects and subcutaneous sites in rats (CROSBI ID 479981)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Zoričić, Sanja ; Marić, Ivana ; Bobinac, Dragica
engleski
BMP-7 induced osteogenesis in partial calvarial bone defects and subcutaneous sites in rats
The osteogenesis induced by rhBMP-7 bound to inactive bone residue (IRBR) implanted in rats have been studied at ectopic and orthotopic sites. IRBR with or without BMP-7 were implanted onto calvarial defects, onto intacted calvaria and subcutaneouslly in thoracic region of rats. Implants were harvested at day 7, 12 and 21 and analysed by histology, histochemistry, histomorphometry and immunohistochemistry. The results showed differences in initial cellular response between implants from different sites. At a subcutaneous sites BMP-7-reconstructed implants induced abundant cartilage on day 7. On the contrary, BMP-7 at calvarial sites induced direct bone formation. On day 21 all implants consisted mainly of bone. In both calvarial sites bone remodeling was active and lamellar bone was already formed. Implants from partial calvarial defect completely fused with the underlying bone. The results of histomorphometry showed more pronounced and rapid osteogenessis in both calvarial implants. In conclusion we suggest that BMP-7 induced different rate of osteogenesis at ectopic vs orthotopic sites.
bone morphogenetic proteins; osteogenesis; ectopic bone
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Podaci o prilogu
S93-S93.
2000.
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objavljeno
Podaci o matičnoj publikaciji
Calcified tissue international. Supplement
Avioli, LV
New York (NY): Springer
0944-0747
Podaci o skupu
European Symposium on Calcified Tissues (27 ; 2000)
poster
06.05.2000-10.05.2000
Tampere, Finska